Author(s)

Modou Ndongo^1*, Babacar Ndiaye¹, Nestor Nankeu², Abou Sy¹, Houyem Attia², Fatiha Lahouel², Djillali Ziane Berroudja², Tayeb Bensalem², Sid Ali Toufik Benyaghla², Catherine Albert², Sidy Mohamed Seck³, El Hadji Fary Ka¹

¹Department of Nephrology, Dialysis and Kidney Transplantation of Aristide Le Dantec Hospital, Dakar, Senegal.
²Department of Nephrology, Dialysis of Louis Pasteur Hospital, Chartres, France.
³Department of Nephrology, Dialysis of Ouakam Military Hospital, Dakar, Senegal.

Introduction: Hypercalcemia is the most common metabolic complication in myeloma. The aim of this study was to evaluate the management strategy of hypercalcemia in myeloma at the nephrology department of Louis Pasteur hospital of Chartres. Patients and Methods: We carried a retrospective study of patients treated for myeloma-related hypercalcemia between January 1, 2019 to December 31, 2021. The clinical, paraclinical, therapeutic and evolutive characteristics were studied. Results: Eight patients were included in this study with a median age of 67 years [41 - 85] and a sex ratio (M/F) of 1. A quarter of patients were known with chronic kidney disease. Four patients (50%) had symptoms of hypercalcemia. Biologically, the mean hemoglobin was 9.8 ± 2.7 g/dl, all patients had an acute kidney injury with a mean creatinine level of 364.1 ± 173.3 mmol/l, a mean serum calcium of 3.42 ± 0.59 mmol/l and three quarter of patients had bone lesions. Five patients (62.5%) were rehydrated with a mean volume of saline of 2700 ± 836.7 ml/24h. Seven patients (87.5%) received biphosphonates and none received diuretics. The mean normalization time of the serum calcium was 5 days. Conclusion: Hypercalcemia is frequent in malignancy and represents a poor prognosis factor of the disease. A well-conducted therapeutic strategy allows rapid normalization.

Hypercalcemia, Myeloma, Treatment, Malignancy, Neoplasia

Ndongo, M. , Ndiaye, B. , Nankeu, N. , Sy, A. , Attia, H. , Lahouel, F. , Berroudja, D. , Bensalem, T. , Benyaghla, S. , Albert, C. , Seck, S. and Ka, E. (2022) Evaluation of the Therapeutic Management of Hypercalcemia in Myeloma at the Nephrology Department of Louis Pasteur Hospital of Chartres: About 8 Cases. Open Journal of Nephrology, 12, 403-409. doi: 10.4236/ojneph.2022.124041.