Author(s)

Jie Chen, Yusha Guo, Ying Wu, Xiaoqin Zhao, Jing Yang^*

Zhuji People’s Hospital, Zhuji, China.

Background: Both 30% supramolecular salicylic acid (SA) and isotretinoin erythromycin gel (IEG) have proven efficacy with good safety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 30% SA peeling and IEG in the treatment of moderate-to-severe acne vulgaris. Methods: Patients with moderate-to-severe acne vulgaris were randomized into 3 groups of 30 persons each, and treated with SA peel, or IEG, or SA combine with IEG (SA + IEG group). Evaluation of acne was done by effective rate and individual lesion counts. And the adverse effects and recurrence were recorded. Results: The SA + IEG group was better in clinical efficacy and treating noninflammatory and inflammatory lesions than that of single treatment group (P < 0.05). No serious adverse effects were recorded. There were no significant differences in adverse effects and recurrence between groups (P > 0.05). Conclusion: 30% SA combined with IEG had a significant effect in the treatment of moderate-to-severe acne lesions.

30% Supramolecular Salicylic Acid, Isotretinoin Erythromycin Gel, Moderate-to-Severe Acne Vulgaris, Efficacy, The Adverse Reactions, Recurrence Rate

Chen, J. , Guo, Y. , Wu, Y. , Zhao, X. and Yang, J. (2022) Efficacy and Safety of 30% Supramolecular Salicylic Acid Peeling Combined with Isotretinoin Erythromycin Gel in the Treatment of Moderate-to-Severe Acne Vulgaris: A Comparative Study. International Journal of Clinical Medicine, 13, 461-467. doi: 10.4236/ijcm.2022.1310033.