Author(s)

Greesha N. Majethia, Wahajul Haq, Ganesaratnam K. Balendiran

Department of Chemistry, Youngstown State University, Youngstown, OH, USA.

A highly efficient and facile protocol for the selective reduction of carboxylic acid of Fenofibric acid to corresponding alcohol was developed. The selective reduction was carried out by activation of carboxylic acid by mixed anhydride followed by the reaction of sodium borohydride in presence of methanol. This is the first example of chemoselective reduction of carboxylic acid to alcohol in presence of a ketone without any external catalyst or ligand in a single step. The reaction offers wide applicability for the selective carboxylic group reduction methodology. The chemoselective reduction was demonstrated by the reduction of Fenofibric acid, an active metabolite of the drug Fenofibrate, to corresponding alcohol in excellent selectivity, yield, and purity.

Chemoselective, Reduction of Carboxylic Acid, Sodium Borohydride, Mixed Anhydride

Majethia, G. , Haq, W. and Balendiran, G. (2022) Chemoselective Reduction of Fenofibric Acid to Alcohol in the Presence of Ketone by Mixed Anhydride and Sodium Borohydride. International Journal of Organic Chemistry, 12, 116-125. doi: 10.4236/ijoc.2022.122010.