Expression and Significance of Regulatory B Cells in Patients with Immune Thrombocytopenia ()
ABSTRACT
Objective: To
detect the expression and significance of regulatory B cells in patients with
immune thrombocytopenia. Methods: 73 ITP patients were divided into
glucocorticoids treatment group (n = 42) and recombinant human thrombopoietin
(rhTPO) treatment group (n = 31). According to the therapeutic effect, it was
divided into effective group and ineffective group. The expression of CD19+
CD24hiCD38hi Breg in peripheral blood was detected by flow cytometry before and
after treatment. The expression levels of transforming growth factor (TGF)-β1, interleukin (IL-10) and interferon
(IFN)-γ were detected by ELISA before
and after treatment. 30 volunteers were selected as the control group. Results: The expression of CD19+ CD24hiCD38hi Breg and cytokines IL-10
and TGF-β1 in 73 ITP patients before
treatment was lower than that in the control group, while the expression of
IFN-γ was higher than that in the
control group (p < 0. 05). The expression levels of CD19+ CD24hiCD38hi Breg,
IL-10 and TGF-β1 in the effective
group were significantly higher than before treatment, while the expression of
IFN-γ was significantly lower than before treatment (p < 0. 05). The expression
of CD19+ CD24hiCD38hi Breg, IFN-γ,
IL-10 and TGF-β1 in the invalid group
had no significant change compared with before treatment. Conclusion: Abnormal expression of CD19+ CD24hiCD38hi Breg and related cytokines is
involved in the pathogenesis of ITP.
Share and Cite:
Qian, W. and Zhang, X. (2022) Expression and Significance of Regulatory B Cells in Patients with Immune Thrombocytopenia.
Open Journal of Blood Diseases,
12, 45-51. doi:
10.4236/ojbd.2022.122005.
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