Author(s)

Jia Yang¹, Yueyang Yu², Zhengze Zhang², Bo Su³, Yun Zheng⁴, Yang Liu^2*

¹The Second Clinical Medical College of Yangtze University/The Radiology Department of Jingzhou Central Hospital, Jingzhou, China.
²Department of Pathogenic Biology, School of Medicine, Yangtze University, Jingzhou, China.
³Department of Medical Morphology, School of Medicine, Yangtze University, Jingzhou, China.
⁴Department of Medical Function, School of Medicine, Yangtze University, Jingzhou, China.

MicroRNAs (miRNAs) are a functional small non-coding RNA and play essential roles in gene regulation indevelopment, differentiation and proliferation. In order to investigate the miRNAs function in Lewis rat hippocampal development, in this study, newborn and adult hippocampi were deliberately selected to analyze the miRNA expression profiles by microarray. Microarray analyses identified 22 differentially expressed miRNAs (>1.5 fold, intersection of two sets). Of these, 12 were down-regulated and 10 were up-regulated during hippocampus development. DAVID Functional Annotation Cluster (FAC) analysis of the 317 predicted target genes of down-regulated miRNAs revealed confident enrichment scores for cell adhesion and neuron development etc., indicating the functional significance and importance of these miRNAs during hippocampal development. Bioinformatic analyses of the differentially expressed miRNAs have identified a number of miRNAs with putative involvement in the hippocampus developing process. This study lays a solid foundation for further studies to clarify the important regulation function of miRNAs in brain tissue.

MicroRNA, Microarray, Hippocampus, Development

Yang, J. , Yu, Y. , Zhang, Z. , Su, B. , Zheng, Y. and Liu, Y. (2022) Microarray Analysis of MicroRNA Expression Profiles in Newborn and Adult Rats Hippocampus. Yangtze Medicine, 6, 24-40. doi: 10.4236/ym.2022.62003.