Author(s)

Toky Rakotoarivo¹, Christian Tomboravo², Malala Razakanaivo³, Narindra Rajaonarison Ny Ony⁴, Clairette Raharisolo⁵, Florine Rafaramino³

¹Department of Oncology, University Hospital Tanambao Antsiranana, Antananarivo, Madagascar.
²Department of Radiology, University Hospital Place Kabary Antsiranana, Antananarivo, Madagascar.
³Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar.
⁴Department of Radiology, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar.
⁵Department of Anatomy Pathology, Institut Pasteur of Madagascar, Antananarivo, Madagascar.

Hepatoid adenocarcinoma of the lung is a rare tumor with a poor prognosis. There are no specific treatment-recommendations for this cancer. We report a 59-year-old man, a former smoker, with this condition. He presented with a cough and computed tomography revealed a pulmonary nodule (50 × 47 × 48 mm) with a right pleural effusion, together with a cerebral right temporal-lobe lesion and a right adrenal lesion. The serum alpha-fetoprotein value was normal. Histological examination via bronchoscopic biopsy revealed an adenocarcinoma. Positive CK7, AE1/AE2, and TTF1 with granular cytoplasmic staining on immunohistochemical study confirmed the diagnosis of hepatoid adenocarcinoma of the lung, stage IV-B. The patient had received chemotherapies (carboplatin-pemetrexed, gemcitabine) and cerebral radiotherapy, but he died at eight months of the treatment as a result of tumor progression.

Hepatoid Adenocarcinoma, Lung, Chemothérapy, Metastasis

Rakotoarivo, T. , Tomboravo, C. , Razakanaivo, M. , Ony, N. , Raharisolo, C. and Rafaramino, F. (2022) Multi-Metastatic Hepatoid Adenocarcinoma of the Lung: Report of Case. Journal of Cancer Therapy, 13, 304-309. doi: 10.4236/jct.2022.135026.