Inter-Observer Variability in the Interpretation of 68Ga-PSMA PET-CT Scan according to PROMISE Criteria ()
ABSTRACT
Aims & Objectives: Aim of the study was to evaluate inter-observer variability in interpretation of Gallium-68 labeled Prostate Specific Membrane Antigen sub-type 11 (68Ga-PSMA-11) Positron Emission Tomography-Computed Tomography PET_CT scan according to Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE) criteria. Method and Materials: Forty-four consecutive patients of prostate cancer were prospectively studied between the duration of January 2021 to June 2021 at Institute of Nuclear Medicine and Oncology (INMOL), Lahore. All PET-CT scans were assessed by a researcher and 3 nuclear physicians and divided into two groups, interpreted in two phases. In the first phase, each group independently evaluated the scans while in the second phase, a consensus meeting was held and all the cases with discordance were discussed. Cohen’s Kappa test was used to measure interobserver variability with the cut-off of K’s alpha < 0.61 that was chosen to indicate substantial disagreement. Results: The study showed 41 out of 44 scans with positive PSMA findings while 03 scans were negative for any PSMA avid disease. In the first phase of image analysis, the level of agreement was slight in T stage (Kappa = 0.068, p = 0.65), moderate in the miN stage (Kappa = 0.46, p = 0.02) and substantial in miM stage (Kappa = 0.77, p ≤ 0.001) was seen. For PSMA score, overall agreement was substantial agreement (Kappa = 0.64, p < 0.01). In the second phase, miT stage and miN stage showed total agreement (Kappa = 1, p < 0.001), and miM stage showed strong agreement (Kappa = 0.90, p < 0.001) while PSMA score in all three stages showed total agreement (Kappa = 0.9, p < 0.01). Conclusion: Remarkable inter-observer agreement was seen in PROMISE criteria.
Share and Cite:
Nasir, A. , Younis, M. , Adnan, S. , Yasmin, T. , Fatima, I. and Shahid, A. (2022) Inter-Observer Variability in the Interpretation of
68Ga-PSMA PET-CT Scan according to PROMISE Criteria.
Advances in Molecular Imaging,
12, 1-13. doi:
10.4236/ami.2022.121001.
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