Author(s)

Dama Faniriantsoa Henrio Marcellin¹, Limin Guo¹, Haiyang Yu¹, Shuchao Wang¹, Paul Pielnaa¹, Adonira Saro¹, Ismail Bilal Masokano², Malik Muhammad Adil³, Ling Yuan⁴, Yanxia Huang¹, Deyang Cai¹, Ruping Zheng¹, Zhongjun Huang¹, Aixiang Luo¹, Cyrollah Disoma⁵, Pinjia Liu⁵, Zanxian Xia^5*, Jufang Huang^1,5*

¹Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
²Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
³Department of Hepatobiliary Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China.
⁴Department of Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
⁵Department of Cell Biology, School of Life Sciences, Central South University, Changsha, China.

Zika virus (ZIKV) is a flavivirus that can be identified as a small envelope with a positive-stranded RNA and an important medical pathogen, which causes deadly human diseases. The virus is carried by Aedes aegypti mosquitoes through a blood meal and it is also spread through body fluids. ZIKV infection may present with symptoms like fever, myalgia, maculopapular rash as well as neurological sequelae, which include, microcephaly, epilepsy, and Guillain Barré syndrome (GBS). This put the virus on a scale of the public health burden of almost 87 countries. The potential threat of ZIKV infection is not completely eradicated in many countries in Africa, America, and the Western Pacific regions. There are no vaccines and treatments available to date. Since ZIKV causes microcephaly in utero by targeting neural progenitor cells, inducing apoptosis, and impairing neurodevelopment, this article hopes to evaluate the neurological disorders associated with the Zika virus infection while elucidating the current trends in the development of vaccines and drugs.

Zika Virus (ZIKV), Microcephaly, Guillain Barré Syndrome, Epilepsy, Neurological Disorders

Marcellin, D. , Guo, L. , Yu, H. , Wang, S. , Pielnaa, P. , Saro, A. , Masokano, I. , Adil, M. , Yuan, L. , Huang, Y. , Cai, D. , Zheng, R. , Huang, Z. , Luo, A. , Disoma, C. , Liu, P. , Xia, Z. and Huang, J. (2022) Zika Virus and Its Association with Neurological Disorders. Advances in Microbiology, 12, 198-217. doi: 10.4236/aim.2022.124016.