Author(s)

Fan Xu¹, Xiao Li², Qingshan Li¹, Xiao Xu³, Wenxin Li², Xiaolei Yu^1*

¹Departments of Oncology, Affiliated Hospital of Chengde Medical College, Chengde, China.
²Departments of Radiology, Affiliated Hospital of Chengde Medical College, Chengde, China.
³Departments of Pharmacy, Affiliated Hospital of Chengde Medical College, Chengde, China.

Objective: The objective is to investigate the effect of Ganoderma lucidum polysaccharide (GLPS) on the oxidative stress induced by doxorubicin (DOX) in cardiomyocytes. Methods: SD rats were divided into control group, DOX group, GLPS low dose and high dose + DOX group. SOD and MDA levels in myocardial tissue were detected in each group. The expression of related proteins in each group was detected by Western blot. Results: GLPS can increase the SOD level and decrease MDA caused by DOX (p < 0.05). GLPS can reduce the increase of p53 content caused by DOX (p < 0.05), and up regulate the antioxidant enzyme HO-1 (p < 0.05), MDM2 (p < 0.05) and Nrf2 (p < 0.05). Conclusion: Ganoderma polysaccharide can improve the oxidative stress injury of myocardial tissue induced by doxorubicin and play a protective role in myocardial tissue.

Doxorubicin, Ganoderma lucidum Polysaccharide, Myocardial Tissue, Antioxidant Capacity

Xu, F. , Li, X. , Li, Q. , Xu, X. , Li, W. and Yu, X. (2022) Effect of Ganoderma lucidum Polysaccharide on Antioxidative Ability of Rats with Myocardial Injury Induced by Doxorubicin. Journal of Biosciences and Medicines, 10, 14-19. doi: 10.4236/jbm.2022.104002.