Author(s)

Serafino Fazio^1*#, Manila Vaccariello^2#, Flora Affuso^3#

¹University Federico II, Naples, Italy.
²Barletta, Italy.
³Gallipoli, Italy.

We report the clinical case of a 40-year-old Italian woman, who soon after her booster vaccination with mRNA-1273 after the two previous vaccinations with BNT162b2, developed severe headache, high fever, and Musculo-skeletal pain. She went to the emergency department, where computerized tomography (CT) scans of chest and brain were performed, resulting in both negative for pathologic findings. On the contrary, white blood count was strongly lowered and D-dimer severely elevated. She improved after treatment with enoxaparin and the blood analyses returned in the normal range after ten days. This case supports the hypothesis that COVID-19 vaccines could increase blood clotting in some predisposed subjects. Therefore, we believe that robust and well-designed clinical trials, considering the evaluation of D-dimer levels, should be performed to eliminate any doubts on this issue.

Adverse Reaction, COVID-19, Vaccination, Blood Clotting

Fazio, S. , Vaccariello, M. and Affuso, F. (2022) A Case of Adverse Reaction to Booster Dose of COVID-19 Vaccination: Could D-Dimer Elevation Suggest Increased Clotting Risk?. Health, 14, 204-208. doi: 10.4236/health.2022.142015.