Author(s)

Davut Cakici, Benan Kilbas^*

Moltek A. S. Gebze Organize Sanayi, Gebze, Kocaeli, Turkey.

Synthesis of novel ²²⁵Ac-Sn particles was described for the first time. Detailed experimental and stability studies were successfully exhibited. Treatment of excess amount of SnCl₂ with 0.2 mCi ²²⁵Ac furnished highly stable ²²⁵Ac tin colloid with 90% of radiochemical yield (RCY) at optimized reaction condition. R-TLC analyses indicated 95% of radiochemical purity (RCP). Stability studies showed that colloidal structure also retained free daughter radionuclides formed by the ²²⁵Ac decay chain. ²²⁵Ac tin colloids could be ideal nanocarriers for localized cell killing due to high linear energy transfer and prevention of free radioisotope daughters.

²²⁵Actinium Tin Colloid, Radiosynovectomy, Stability, Targeted Alpha-Particle Therapy

Cakici, D. and Kilbas, B. (2022) Synthesis and Stability Studies of ²²⁵Actinium Tin Colloid Radiopharmaceutical. Advances in Nanoparticles, 11, 23-30. doi: 10.4236/anp.2022.111003.