Author(s)

Hathaikan Chootrakool, Pichet Treewai

Department of Biostatistics, Faculty of Public Health, Mahidol University, Bangkok, Thailand.

Most meta-analysis has concentrated on combining of treatment effect measures based on comparisons of two treatments. Meta-analysis of multi-arm trials is a key component of submission to summarize evidence from all possible studies. In this paper, an exact binomial model is proposed by using logistic regression model to compare different treatment in multi-arm trials. Two approaches such as unconditional maximum likelihood and conditional maximum likelihood have been determined and compared for the logistic regression model. The proposed models are performed using the data from 27 randomized clinical trials (RCTs) which determine the efficacy of antiplatelet therapy in reduction venous thrombosis and pulmonary embolism.

Meta-Analysis, Multi-Arm Trials, Binomial Approach

Chootrakool, H. and Treewai, P. (2022) Meta-Analysis of Multi-Arm Trials Using Binomial Approach. Open Journal of Statistics, 12, 15-32. doi: 10.4236/ojs.2022.121002.