Author(s)

Philip Kioko Ndonye¹, Samuel Nii Adu Tagoe²

¹Oncology & Cancer Treatment Centre, The Nairobi Hospital, Nairobi, Kenya.
²School of Biomedical & Allied Health Sciences, University of Ghana/Korle Bu Teaching Hospital, Accra, Ghana.

Purpose: To test the concept of Statistical Process Control (SPC) as a Quality Assurance (QA) procedure for dose verifications in external beam radiation therapy in conventional and 3D Conformal Radiotherapy (3D-CRT) treatment of cervical cancer. Materials and Methods: A study of QA verification of target doses of 198 cervical cancer patients undergoing External Beam Radiotherapy (EBRT) treatments at two different cancer treatment centers in Kenya was conducted. The target doses were determined from measured entrance doses by the diode in vivo dosimetry. Process Behavior Charts (PBC) developed by SPC were applied for setting Action Thresholds (AT) on the target doses. The AT set was then proposed as QA limits for acceptance or rejection of verified target doses overtime of the EBRT process. Result and Discussion: Target doses for the 198 patients were calculated and SPC applied to test whether the action limits set by the Process Behavior Charts could be applied as QA for verified doses in EBRT. Results for the two sub-groups of n = 3 and n = 4 that were tested produced action thresholds which are within clinical dose specifications for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. Conclusion: Action thresholds set by SPC were within the clinical dose specification of ±5% uncertainty for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. So the concept of SPC could be applied in setting QA action limits for dose verifications in EBRT.

Quality Assurance, Statistical Process Control, Action Thresholds, Dose Verification, External Beam Radiation Therapy

Ndonye, P. and Tagoe, S. (2022) Application of Statistical Process Control for Setting Action Thresholds as Quality Assurance of Dose Verifications in External Beam Radiotherapy. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 11, 22-35. doi: 10.4236/ijmpcero.2022.111003.