Author(s)

Prince Eliot Galieni Sounga Bandzouzi^1,2*, Ghislain Armel Mpandzou^1,3, Josué Euberma Diatewa^1,3, Dina Happia Motoula-Latou^1,3, Charles Godefroy Koubemba², Paul Macaire Ossou-Nguiet^1,3, Donatien Moukassa¹

¹Faculty of Health Sciences, Marien N’Gouabi University, Brazzaville, Republic of Congo.
²Department of Neurology, Loandjili General Hospital, Pointe-Noire, Republic of the Congo.
³Department of Neurology, University Hospital Center of Brazzaville, Brazzaville, Republic of Congo.

Objective: To determine the role of CD4+ and CD8+ T lymphocytes in the onset of stroke in people living with HIV. Methodology: This was a descriptive, cross-sectional study from January to July 2019, in the neurology department of loandjili general hospital, including any patient hospitalized for a first episode of stroke confirmed by brain scan. The study variables were: age, sex, CRP value, serum T cell CD4+, CD8+. The statistical analysis was carried out using the EPI info 7 software. Results: Twenty stroke patients were included. The relative frequency of HIV was 20%. The risk factors were potentiated by immunosuppression of CD4+ T cells. Sixty percent (60%) of the patients had a CD4+ count < 200/mm³ and the mean CD4+ count was ±191/mm³. Stroke was the predominant mechanism of injury with a frequency of 70%, the only injury mechanism of stroke in patients with CD8+ T cell count > 800/mm³ (p = 0.04). Conclusion: Risk factors are potentiated by TCD4+ lymphocyte immunosupression, also CD8+ lymphocytes of immune system activation marker are a cardiovascular risk factor for living people with HIV.

CD4+, CD8+ T Lymphocytes, HIV, Stroke, Pointe-Noire

Sounga Bandzouzi, P. , Mpandzou, G. , Diatewa, J. , Motoula-Latou, D. , Koubemba, C. , Ossou-Nguiet, P. and Moukassa, D. (2022) Role of CD4+ and CD8+ T Lymphocyte in the Onset of Stroke in People Living with HIV in Pointe-Noire. World Journal of Neuroscience, 12, 1-7. doi: 10.4236/wjns.2022.121001.