Author(s)

Oumar Coulibaly^1*, Hawa Gouro Diall¹, Guédiouma Dembélé², Mamary Coulibaly¹, Fatoumata Léonie Françoise Diakité¹, Lala Ndrayni Sidibé¹, Leyla Maiga¹, Ibrahima Ahamadou¹, Abdoul Karim Doumbia¹, Belco Maiga¹, Adama Dembelé¹, Pierre Togo¹, Karamoko Sacko¹, Mohamed Elmouloud Cissé¹, Djeneba Konaté¹, Fousseyni Traoré¹, Aminata Doumbia¹, Yacouba Aba Coulibaly¹, Amadou Touré¹, Bourama Kané², Issa Amadou Touré³, Abdoul Aziz Diakité¹, Traoré Fatoumata Dicko Traoré¹, Mariam Sylla¹, Boubacar Togo¹

¹Department of Pediatrics, CHU Gabriel Touré, Bamako, Mali.
²Department of Pediatrics, Mali Hospital, Bamako, Mali.
³Department of Pediatric Surgery, CHU Gabriel Touré, Bamako, Mali.

Objective: Early bacterial neonatal infection (INBP) or maternofetal infection (early neonatal sepsis) remains a concern of the pediatrician due to diagnostic difficulties and its increased morbidity and mortality. No study has been done in Mali on the profile of newborns admitted for INBP with positive CRP, hence the initiation of this work with the aim of studying the epidemiological, biological and bacteriological profile of newborns with a bacterial maternal-fetal infection. Method: Longitudinal study descriptive (from 27 June to 3 September 2016) which concerned all newborns aged from 0 to 72 hours of life hospitalized for confirmed early bacterial neonatal infection with a positive C-reactive protein (CRP) in the neonatal department of the CHU Gabriel Touré. INBP was defined by the presence of maternal and neonatal infectious risk factors, positivity of CRP with a germ in the blood culture. Results: During the study period we included 244 newborns for probable maternofetal infection and who benefited from the CRP assay, 43 had a positive CRP, i.e. a frequency of 17.62%. The sex ratio was 2.30. The majority had a low birth weight (<2500 g) in 69.8% of cases. Mothers were aged 18 to 35 in 93%. The majority were out of school (43.8%) and housewives in 74.4%. The main reasons for consultations were prematurity and/or low birth weight, respiratory distress and neonatal distress, i.e. 46.5%, 25.6% and 11.6% respectively. Among the 43 newborns with a positive CRP, the blood culture returned positive in 79.1% (n = 34). We deplore 2 deaths (4.7%). The main bacteria were gram-positive cocci (Staphylococcus aureus 53.01% and Streptococccus agalactiae 4.10%), gram-negative bacilli (GNB) type Enterobacteriaceae (Klebsiella pneumoniae 11.25% and E. coli at 5.70%) and non-fermentative GNBs (Pseudomonas aeruginosa 2.80% and Acinetobacter baumannii complex 2.24%). Conclusion: Maternal-fetal infection is a hospital pathology frequently encountered in the neonatal period. Its clinical presentation is dominated by respiratory distress, neurological disorders and low birth weight.

Early Bacterial Neonatal Infection, Clinical Profile, Neonatal Mortality

Coulibaly, O. , Diall, H. , Dembélé, G. , Coulibaly, M. , Diakité, F. , Sidibé, L. , Maiga, L. , Ahamadou, I. , Doumbia, A. , Maiga, B. , Dembelé, A. , Togo, P. , Sacko, K. , Cissé, M. , Konaté, D. , Traoré, F. , Doumbia, A. , Coulibaly, Y. , Touré, A. , Kané, B. , Touré, I. , Diakité, A. , Traoré, T. , Sylla, M. and Togo, B. (2021) Profile of Newborns Hospitalized for Maternal Fetal Infection and Having a Positive CRP in the Pediatric Department of the Gabriel Touré CHU in Bamako, Mali. Open Journal of Pediatrics, 11, 684-693. doi: 10.4236/ojped.2021.114064.