Author(s)

M. Daou^1*, M. Sidibé², A. Andia³, M. J. Y. Araoye¹, M. Konaté³, Z. Mamadou², Y. Abba Kaka⁴, D. I. Bako⁵, S. Beydou¹, S. Brah³, L. Salissou¹, E. Adehossi³, S. Sanoussi⁴

¹Department of Internal Medicine, Hôpital National de Niamey, Niamey, Niger.
²Department of Neurology, Hôpital National de Niamey, Niamey, Niger.
³Department of Internal Medicine, Hôpital General de Reference, Niamey, Niger.
⁴Department of Surgery, Hôpital National de Niamey, Niamey, Niger.
⁵Department of Radiology, Hôpital General de Reference, Niamey, Niger.

We report three cases of neurofibromatosis type 1 disease with literature review, collected in the department of neurology and internal medicine from National Hospital of Niamey (HNN). Two of them were men and the first signs were noted by the mother at the birth in 2 cases. Only one case of consanguinity was observed. Clinically, light brown spots on the skin, neurofibromas, Lisch nodules were constantly observed. Histopathological’s exam confirmed neurofibromas. Moreover, cutaneous and ophthalmological manifestations lead to the diagnostic. Two cases of orthopedic complications were observed: one scoliosis and one Congenital dysplasia of the long bones. There was no specific treatment. Neurofibromatosis type 1 or von Recklinghausen’s disease is the most frequent phacomatosis and its diagnosis is usually composed of a set of clinical criteria of the National Institute Health (Bethesda, 1988).

Von Recklinghausen Disease, NIH Criteria, Niger

Daou, M. , Sidibé, M. , Andia, A. , Araoye, M. , Konaté, M. , Mamadou, Z. , Kaka, Y. , Bako, D. , Beydou, S. , Brah, S. , Salissou, L. , Adehossi, E. and Sanoussi, S. (2021) Neurofibromatosis Type 1 or Von Recklinghausen Disease: About Three Cases to the National Hospital of Niamey and Literature Review. Open Journal of Internal Medicine, 11, 175-187. doi: 10.4236/ojim.2021.113013.