Author(s)

Gang Yang^1*#, Zhanwei Ruan^2*, Chenbing Wang¹, Chao Gu¹, Junjie Lv¹, Shaojun Yang¹, Lulu Weng¹, Feng Ding¹, Long Ai¹, Donghai Yuan¹, Fei Chen¹, Jiangli Chen¹, Gaofeng Shao¹

¹Department of Neurosurgery, Zhuji Affiliated Hospital of Shaoxing University, Shaoxing, China.
²Department of Emergency, The Third Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.

Mesenchymal Stem Cells (MSCs) are a type of non-hematopoietic progenitor cells which have self-replication capacity and multilineage differentiation. They have widely applied in studies of various diseases due to their effects in damaged tissue repair, neuroprotection and immunoregulation. MSCs can secret exosomes through multiple ways in the physiological or pathological state. Many researches’ results on MSC-Exo show that it possesses many functions similar to MSCs, such as immunoregulation and regeneration promotion of damaged tissues. Hence, MSC-Exo is believed to have considerable research potentials in regenerative medicines. This study reviewed the research progresses on biological characteristics and functions of MSC-Exo.

Bone Mesenchymal Stem Cell-Derived Exosome, Blood-Brain Barrier, Intracerebral Hemorrhage

Yang, G. , Ruan, Z. , Wang, C. , Gu, C. , Lv, J. , Yang, S. , Weng, L. , Ding, F. , Ai, L. , Yuan, D. , Chen, F. , Chen, J. and Shao, G. (2021) Research Progresses in the Inhibitory Effect of Bone Mesenchymal Stem Cell-Derived Exosome on Blood-Brain Barrier Disruption following Intracerebral Hemorrhage in Rats. Journal of Biosciences and Medicines, 9, 125-137. doi: 10.4236/jbm.2021.99011.