Author(s)

Catherine C. Baucom^1,2, Xian-Peng Jiang^2*

¹The Mastology Center, Baton Rouge, Louisiana, USA.
²Sallie Astor Burdine Breast Foundation, Baton Rouge, Louisiana, USA.

COVID-19 severe symptoms and high mortality are mainly seen in elders with age-associated diseases who have mitochondrial dysfunction. Mitochondrial dysfunction is a vulnerability and comorbidity of COVID-19. Cytokine storm, and increased serum iron and ferritin and reactive oxygen species (ROS) in COVID-19 further damage mitochondria. Amelioration of mitochondrial dysfunction may be a strategy of prevention and treatment of COVID-19. We also describe mitochondrial organelle transplantation (MOT) which has restored mitochondrial function, improved the repair of injured tissues and suppressed hyperinflammation in life-threatening sepsis. MOT is a potential therapy for severe COVID-19. Finally, we report the first case of MOT for a severe COVID-19 patient. MOT is safe and might have beneficial effect on the severe COVID-19.

COVID-19, Mitochondrial Dysfunction, Mitochondrial Organelle Transplantation, Lung Repair

Baucom, C. and Jiang, X. (2021) Mitochondrial Organelle Transplantation Is a Potential Therapeutic for Mitochondria Dysfunction in Severe Acute Respiratory Syndrome (SARS) Coronavirus Diseases. Advances in Infectious Diseases, 11, 298-309. doi: 10.4236/aid.2021.113027.