Lipopolysaccharide Binding Protein and Cardiovascular Changes in Obese Children ()
ABSTRACT
Objective: Despite the growing evidence that lipopolysaccharide
binding protein (LBP) plays a major role in cardiovascular disease (CVD)
pathophysiology and obesity, data regarding
this association in children are rare. Therefore, our objectives were to
assess whether there was a difference between overweight/obese and
normal-weight children in plasma LBP levels and to assess the cardiovascular
changes in both groups. Methods: In an observational, case-control study, a total of
30 children as obese and overweight children. Obese children with body mass index (BMI) above 95th percentile, and overweight children with BMI between 85th and 95th percentile were recruited if they aged between 8-16 years old. A similar number of matched
controls were included. Serum LBP was measured by enzyme-linked immunosorbent
assay (ELISA) technique. Results: With regard to serum LBP, the mean LBP was significantly higher in obese
children than in the control group (52.74 ± 17.25 versus 12.34 ± 2.67 μg/mL, respectively; p < 0.001). The ROC curve showed
that the serum LBP, at a cutoff value of >19 μg/mL, was a significant discriminator of obesity with a sensitivity of 96.67% and
specificity of 100%. The regression analysis showed that BMI was an independent predictor of
serum LBP (B coefficient = 0.684; p = 0.024). The serum
LBP correlated significantly with age (r = 0.58; p = 0.001), BMI (r = 0.834; p = 0.001), and LV longitudinal strain (r = 0.362; p = 0.05). Conclusion: In conclusion, our findings showed that obesity was
associated with a worse lipid profile and cardiovascular function. LBP is a promising
predictor of obesity in children.
Share and Cite:
Mansour, E. , Elwakeel, M. , Elaziz, O. and Shipl, W. (2021) Lipopolysaccharide Binding Protein and Cardiovascular Changes in Obese Children.
Open Journal of Pediatrics,
11, 225-237. doi:
10.4236/ojped.2021.112022.
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