Clinical Utility of Tumor Markers - Open Journal of Pathology

OJPathology > Vol.11 No.2, April 2021

Open Journal of Pathology

Volume 11, Issue 2 (April 2021)

ISSN Print: 2164-6775 ISSN Online: 2164-6783

Google-based Impact Factor: 0.31 Citations

Clinical Utility of Tumor Markers ()

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DOI: 10.4236/ojpathology.2021.112005 1,153 Downloads 6,863 Views Citations

Author(s)

Taro Mizuno¹, Takayuki Goto², Kota Shimojo³, Naoki Watanabe⁴, Takuji Tanaka^4,5*

Affiliation(s)

¹Department of Medical Oncology, Nagoya Medical Center, Nagoya, Japan.
²Department of Hematology, Gifu Municipal Hospital, Gifu City, Japan.
³Department of Internal Medicine, Gifu Municipal Hospital, Gifu City, Japan.
⁴Department of Diagnostic Pathology & Research Center of Diagnostic Pathology, Gifu Municipal Hospital, Gifu City, Japan.
⁵Center of Genomic Medicine, Gifu Municipal Hospital, Gifu City, Japan.

ABSTRACT

Tumor markers comprise a wide spectrum of biomacromolecules excessively synthesized by a variety of neoplastic cells. These markers can be endogenous products of highly active metabolites from malignant neoplastic cells or the products of newly activated genes. Ideally, tumor markers should be highly sensitive, specific, and reliable with a high prognostic value and organ specificity. In addition, they should reflect the tumor stage. However, no tumor markers identified thus far have all of these characteristics. Nevertheless, most tumor markers show excellent clinical relevance for monitoring the efficacy of a variety of therapies. We herein review how to use the recommended tumor markers to diagnose malignancies, such as gastrointestinal carcinoma, liver cancer, bile duct/pancreatic cancer, lung cancer, breast cancer, gynecologic cancer, and urologic cancer.

KEYWORDS

Tumor Marker, Neoplastic Cells, Tumor Stage, Prognosis, Monitor, Therapeutic Effects

Share and Cite:

Mizuno, T. , Goto, T. , Shimojo, K. , Watanabe, N. and Tanaka, T. (2021) Clinical Utility of Tumor Markers. Open Journal of Pathology, 11, 38-57. doi: 10.4236/ojpathology.2021.112005.

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