Author(s)

Hani Alothaid¹, Umama Yezdani², Mahmoud M. Habibullah³, Saad Saeed Alamri⁴, Mazen M. Ghaith⁵, Mohammad Gayoor Khan^6*

¹Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia.
²Department of Pharmacy Practice, MRM College of Pharmacy, Hyderabad, India.
³Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
⁴Research Center, King Fahad Medical City, Riyadh, Saudi Arabia.
⁵Laboratory Medicine Department, Faculty of Applied Medical Science, Umm Al-Qura University, Makkah, Saudi Arabia.
⁶UCB Unit, Department of Pharmacovigilance, Bioclinica, Mysore, India.

Background: Breast lymphomas are typical extranodal types of lymphoma, also known as Extranodal-lymphoma (ENL), which occur extremely infrequently, aggregating into a very small proportion of malignant breast tumors. The rarity of breast lymphomas is attributed to the scant lymphoid tissue content of the chest wall. Aims of Study: This case report is aimed at providing an up-to-date review of the literature on breast lymphomas for clinicians to, therefore, consider the possibility of this disease entity while treating a breast mass. Case Presentation: A case was reported of a 52-year man with chief mammary non-Hodgkin breast ENL when fine-needle aspiration cytology (FNAC) was not leading to a firm conclusion or result. Following an incisional biopsy, he was found to have a primary breast lymphoma. Later, the patient was diagnosed with the diffuse large B-cell type of lymphoma also known as non-Hodgkin’s Lymphoma (NHL). He had a complete reduction and disappearances of all the signs and symptoms of the disease after a course of neoadjuvant chemotherapy: Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone (CHOP). CONCLUSION: Based on the above case presentation, it is vital for health care professionals and oncologists to recognize the disease by assessing the breast mass accurately with more entities so that proper diagnosis via core biopsy (incisional biopsy) can eliminate the PBL before further treatment is required.

Non-Hodgkin’s Lymphoma, PBL, B-Cell Lymphoma, Breast Cancer, CHOP, ENL

Alothaid, H. , Yezdani, U. , Habibullah, M. , Alamri, S. , Ghaith, M. and Khan, M. (2021) Rare Primary Diffuse Large B-Cell Lymphoma of a Male Breast. Case Reports in Clinical Medicine, 10, 99-107. doi: 10.4236/crcm.2021.104012.