Author(s)

Kanta Ka^1,2*, Abdoul Halim Bague³, Ibrahim Mounkeila⁴, Mamadou Lassana Foba⁵, N. Zongo³, Davide Soldato², Filippo Dall’Olio², Mamadou Moustapha Dieng⁶, Papa Macoumba Gaye^1,6, Daniele Presti^2,7

¹Radiotherapy Department, Centre Hospitalier National Universitaire Dalal Jamm de Guédiawaye, Guédiawaye, Senegal.
²School of Cancer Sciences, Paris Sud, Orsay, French.
³Unité D’oncologie Chirurgicale, CHU Yalgado Ouedraogo, Ouagadougou, Burkina Faso.
⁴Servie d’Oncologie Institut Joliot Curie, Centre Hospitalier Universitaire Aristide Le Dantec, Dakar, Senegal.
⁵Department of Plastic Surgery, Aristide Le Dantec University Hospital, Dakar, Senegal.
⁶University Cheikh Anta Diop of Dakar, Dakar, Senegal.
⁷Medical Oncology Service, ICS Maugeri IRCCS SpA, University of Pavia, Pavia, Italy.

Background: Phylloid sarcomas are rare. There is not enough data to codify the management. Objectives: The objective was to study the clinical and therapeutic aspects and the fate of patients after a follow-up of at least 4 years. Thus contributing to the limited body of knowledge on these tumors. Methods: a retrospective analysis of the files from 2013 to 2017 was carried out and patients were followed up until 2021at Hassan II Hospital. Epidemiological, clinical and therapeutic aspects were studied. Survival was calculated using the Kaplan-Meier method. Results: We collected 12 charts of patients treated for phyllodeal sarcoma from 2013 to 2017. The median age was 43 years. The circumstance of discovery was marked by the presence of nodule in all patients. The coupled echo-mammography examination classified the nodules, ACR 4 in 7 patients and ACR 3 in 3 and ACR 5 in 2 patients. Histological examination revealed a phylloid sarcoma in 11 patients and a borderline phylloid tumor in 1 patient. All patients had radical surgery with positive margins in 2 patients, 16.66%. One patient had revision surgery. Histological examination of the surgical specimens showed phylloid sarcoma on all specimens. All patients had adjuvant radiotherapy with doses of 50 Gy in 25 fractions of 2 Gy and a boost of 10 Gy was done in one patient. The median spread of radiotherapy was 37 days. Grade 1 and 2 skin toxicities were noted in 5 and 3 patients respectively. The median time from surgery to radiotherapy was 2.95 months. 3 patients relapsed after 13.6 months of follow-up. The recurrence-free survival at 1 and 3 years was 83% and 75% respectively. Overall survival at 3 and 5 years was 83% and 75% respectively. Conclusion: This is a rare entity which requires randomized trials to codify its management. It would seem that the multidisciplinary approach, associating surgery ± radiotherapy, is a good option.

Phylloid Sarcoma, Radiotherapy, Survival

Ka, K. , Bague, A. , Mounkeila, I. , Foba, M. , Zongo, N. , Soldato, D. , Dall’Olio, F. , Dieng, M. , Gaye, P. and Presti, D. (2021) Management of Phylloid Sarcomas: A Retrospective Study of 12 Cases. Advances in Breast Cancer Research, 10, 25-33. doi: 10.4236/abcr.2021.102002.