Cytotoxicity of Mongolian Medicine Aconitum kusnezoffii - Chinese Medicine

CM > Vol.12 No.1, March 2021

Chinese Medicine

Volume 12, Issue 1 (March 2021)

ISSN Print: 2151-1918 ISSN Online: 2151-1926

Google-based Impact Factor: 0.72 Citations

Cytotoxicity of Mongolian Medicine Aconitum kusnezoffii ()

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DOI: 10.4236/cm.2021.121002 359 Downloads 1,208 Views Citations

Author(s)

Xiong Su¹, Xiaoyu Gao², Lijuan Shang³, Zhiqiang Li², Wancheng Zhao², Baofeng Chi¹, Shiqi Wang¹, Hairong Zhang¹, Dejun Sun^2*, Juan Sun^2*

Affiliation(s)

¹Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.
²Inner Mongolia People’s Hospital, Hohhot, Inner Mongolia Autonomous Region, China.
³Hohhot Mongolian Traditional Medicine and Chinese Medicine Hospital, Hohhot, Inner Mongolia Autonomous Region, China.

ABSTRACT

Aconitum kusnezoffii used as an analgesic and anti-inflammatory. It is often used not only in Mongolian medicine but also in traditional Chinese medicine. However, there are few studies on its impact of inflammatory cytokines. This study explored the effects of Aconitum kusnezoffii in vitro used human colon cancer (Caco-2) cells. Cytotoxicity was assessed by measuring effects on expression of IL-1β, IL-6, IL-8, and TNF-α used enzyme-linked immunosorbent assay (ELISA). In vitro study demonstrated that incubation of Caco-2 cells with some kinds of Aconitum kusnezoffii at some concentrations inhibit secretion of TNF-α and FAXIU ACONITUM KUSNEZOFFII could inhibit the secretion of IL-1β. While IL-6 and IL-8 levels were unaffected after 24 h of treatment with Aconitum kusnezoffii, qujian Aconitum kusnezoffii, faxiu Aconitum kusnezoffii.

KEYWORDS

Aconitum kusnezoffii, Cytotoxicity, Proinflammatory Cytokines

Share and Cite:

Su, X. , Gao, X. , Shang, L. , Li, Z. , Zhao, W. , Chi, B. , Wang, S. , Zhang, H. , Sun, D. and Sun, J. (2021) Cytotoxicity of Mongolian Medicine Aconitum kusnezoffii. Chinese Medicine, 12, 10-18. doi: 10.4236/cm.2021.121002.

Cited by

[1]	Cardiotoxicity Effects of Herbal Medicine, A Review Article
	Biology, Medicine, & Natural Product Chemistry, 2023

[2]	Classification of diterpenoid alkaloids from Aconitum kusnezoffii Reichb. by liquid chromatography‐tandem mass spectrometry‐based on molecular networking
	Journal of …, 2022

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