Evaluation of Red Cell Distribution Width and Platelet Indices in Children with Chronic Heart Disease ()
ABSTRACT
Background: Platelets play a key role in the development and progression of
cardiovascular diseases. Also red cell distribution width (RDW%) & platelet
indices are a good predictor of clinical outcomes. Purpose: Study the relationship between RDW%, platelets count, mean platelet
volume (MPVfl) and platelet distribution width (PDWfl) in children with
congenital heart disease (CHD) or rheumatic
heart diseases (RHD). Subjects and Methods: The study
was carried on 151 children diagnosed as CHD or RHD selected from pediatric
department of Al-Zahraa University Hospital and National Heart Institute. They were aged from 6 months to 12 years.
Another 80 apparently healthy children were taken as controls. Complete
blood count and echocardiography examination were evaluated for all
participants. Results: The mean value of RDW% was increased
in CHD and RHD than controls, RDW% higher in cyanotic CHD (CCHD) (either
decompensated or compensated) than acyanotic CHD, and in decompensated RHD than
compensated RHD with more than one valve affection. The mean platelets count
were decreased in cyanotic than acyanotic CHD, platelets count were increased
in decompensated than compensated RHD either
with one valve or more than one valve affection. The mean values of MPV
and PDW were increased in decompensated CHD, but it decreased in decompensated
RHD. Conclusion: The RDW%, MPV and PDW considered as simple markers in
the follow up of patients with CHD or RHD for early detection of serious
complication.
Share and Cite:
Hussein, H. , Al-Gohary, E. , Mohamed, A. and Abd El-Salam, A. (2021) Evaluation of Red Cell Distribution Width and Platelet Indices in Children with Chronic Heart Disease.
Open Journal of Pediatrics,
11, 78-99. doi:
10.4236/ojped.2021.111008.