Author(s)

Maping Huang¹, Heyi Zhen², Tianhai Huang¹, Xiaoyi Yang¹, Qiuling Liu¹, Qingqing Li¹, Hui Chen^1*

¹Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital, Guangzhou, China.
²Department of Traumatic Brain Injury Rehabilitation, Guangdong Province Work Injury Rehabilitation Hospital, Guangzhou, China.

Objective: To evaluate the efficacy and safety of Combined detrusor and external urethral sphincter BTX-A injections for detrusor overactivity (DO) and detrusor external sphincter dyssynergia (DESD) secondary to spinal cord injury. Study Design: Prospective study. Methods: The study was carried out in 18 SCI patients with detrusor overactivity (DO) and detrusor external sphincter dyssynergia (DESD) receiving Combined detrusor and external urethral sphincter BTX-A injections treatment. Contain 200 U botulinum toxin intradetrusor and 100 U external urethral sphincter injections. The effective outcomes included maximum detrusor pressure at first DO and DESD (PdetmaxDO-DESD), volume at first DO and DESD (VDO-DESD), maximum urethral closure pressure (MUCP), and Incontinence-Specific Quality-of-Life Instrument (I-QoL). Adverse events were recorded. Results: All patients experienced a significant mean reduction in PdetmaxDO-DESD (50.75%), maximum urethral closure pressure (26.34%) and a significant mean increase in VDO-DESD (63.00%) 12-weeks post-injection. Significant (p < 0.001) improvement in mean Incontinence-Specific Quality-of-Life Instrument was also found. No obvious adverse event and toxic effect was observed. Conclusion: Combined detrusor and external urethral sphincter BTX-A injections is a good choice for patients with DO and DESD secondary to spinal cord injury. It could not only protect the upper urinary tract but also improve quality of life.

Detrusor Overactivity, Detrusor External Sphincter Dyssynergia, BTX-A, Spinal Cord Injury

Huang, M. , Zhen, H. , Huang, T. , Yang, X. , Liu, Q. , Li, Q. and Chen, H. (2021) Combined Detrusor and External Urethral Sphincter BTX-A Injections for Detrusor Overactivity and Detrusor External Sphincter Dyssynergia Secondary to Spinal Cord Injury. Open Journal of Urology, 11, 45-51. doi: 10.4236/oju.2021.112006.