Author(s)

David S. Younger

Department of Neuroscience, City University of New York Medical School, New York NY, USA.

Aim: To describe post-infectious neurological aspects of COVID-19 in a patient with progressive post-infectious peripheral (PNS), autonomic (ANS) and central nervous system (CNS) involvement due to SARS-CoV-2 infection. Background and Purpose: A variety of neurological manifestations have been described in association with Covid-19, however, progressive multisystem neurological aspects have not been described. Methods: A case report detailing the history, examination, and infectious serology associated with SARS-CoV-2, and subsequent neurodiagnostic laboratory testing and treatment. Results: Neurodiagnostic laboratory studies showed large-fiber demyelinating sensorimotor and painful small fiber sensory polyneuropathy, orthostatic hypotension, and hypometabolism of bilateral anterior and mesial temporal lobes with a possible frontal seizure focus. Treatment was initiated with high-dose immune globulin therapy. Conclusions: The combination of PNS, ANS and CNS involvement in this patient was associated with post-infectious acquired immunity to SARS-CoV-2.

COVID-19, SARS-CoV-2, Long Hauler, Long Covid, Peripheral Neuropathy, Dysautonomia, Encephalopathy, Encephalitis, EMG NCS, Tilt Table Test, Epidermal Nerve Fibers, PET/MRI

Younger, D. (2021) Post-Acute Sequelae of SARS-Cov-2 Infection Associating Peripheral, Autonomic and Central Nervous System Disturbances: Case Report and Review of the Literature. World Journal of Neuroscience, 11, 17-21. doi: 10.4236/wjns.2021.111003.