Author(s)

J. F. Nnang Essone^1,2, K. Nzé Pascal³, G. Edjo Nkhilli⁴, N. Ekegue^1,2, Diaw Mor⁵, C. P. Akagha Kondé⁶, P. Nzoghe Nguéma², E. Anyunzok⁷, E. R. Obame², C. Allognon⁶, B. Nguéma Asseko⁸, F. Ovono Abessolo⁹, E. Ngou Milama⁹

¹Department of Physiology, Faculty of Medicine and Health Sciences of Libreville (USS), Libreville, Gabon.
²Department of Anesthesia and Emergency Resuscitation, The University Hospital of Owendo, Libreville, Gabon.
³Department of Anesthesia and Emergency Resuscitation, The Mother Child University Hospital Center, Libreville, Gabon.
⁴Department of Anesthesia and Resuscitation, The Army Instruction Hospital, Libreville, Gabon.
⁵Laboratory of Biology and Physiological Functional Explorations, UCAD, Dakar, Senegal.
⁶Department of Medicine, The University Hospital of Libreville, Libreville, Gabon.
⁷Department of Epidemiology, Biostatistics and Medical Mathematics, USS, Libreville, Gabon.
⁸Department of Surgery, The University Hospital of Libreville, Libreville, Gabon.
⁹Department of Chemistry-Biochemistry, Faculty of Medicine and Health Sciences, USS, Libreville, Gabon.

Introduction: The involvement of the endothelial dysfunction (ED) in arterial hypotension (AHPT) post of spinal anesthesia (SA) has not been established. Objective: To determine if there is a relationship between ED and AHPT observed during the 1st 15 minutes after SA. Population and Methods: The study concerned 40 people who were to benefit from a programmed herniorrhaphy under SA and 40 controls (SA^-). The correlations between mean plasma concentrations of endothelin-1 (CmET-1, pg/ml) and Vascular Cell Adhesion Molecule-1 (CmVCAM-1, pg/ml) taken from SA⁺ one hour before (H0), then 15 minutes after the SA (H15) and the mean arterial pression (AMP, mmHg) with heart rate (bpm) were analyzed (p < 5%). Results: CmET-1 and CmVCAM-1 of SA^- were 1.07 and 3.34, respectively, compared to 1.12 (p = 0.735) and 3.57 (p = 0.862) in SA⁺ at H0 and H15. In SA+, at H15, CmET-1 was 1.13 (p = 0.823) and CmVCAM-1 was 3.57 (p = 0.257). In SA^-, a negative correlation existed between CmET-1 and CmVCAM-1 (r = -0.438; p = 0.005). Conversely, in SA⁺, whether at H0 (r = -0.31; p = 0.051) or at H15 (r = 0.024; p = 0.883), no correlation existed between CmET-1 and CmVCAM-1, nor between MAP and ED markers (r = 0.111; p = 0.325). Conclusion: These results show that there is no relationship between the AHPT which occurs during the first fifteen minutes post SA, CmVCAM-1 and CmET-1. Moreover, these data suggest that ED is not involved in AHPT post SA.

Endothelin-1, VCAM-1, Hypotension, Endothelial, Dysfunction, Spinal, Anesthesia

Essone, J. , Pascal, K. , Nkhilli, G. , Ekegue, N. , Mor, D. , Kondé, C. , Nguéma, P. , Anyunzok, E. , Obame, E. , Allognon, C. , Asseko, B. , Abessolo, F. and Milama, E. (2021) Is There a Relationship between Endotheline-1, Vascular Cell Adhesion Molecule-1 and the Arterial Hypotension Observed during Spinal Anesthesia?. Journal of Biosciences and Medicines, 9, 64-85. doi: 10.4236/jbm.2021.91006.