The Association of Visceral Adiposity Index with Insulin Resistance in Adults with Prediabetes ()
Affiliation(s)
1Department of Emergency, Kurmitola General Hospital, Dhaka, Bangladesh.
2Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
3Department of Biochemistry, Ibrahim Medical College (IMC), 1/A Ibrahim Sarani, Segunbagicha, Dhaka, Bangladesh.
4Intensive Care Unit, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders
(BIRDEM), Shahbag, Dhaka, Bangladesh.
ABSTRACT
Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the literature. This study is aimed to determine the association of visceral adiposity index (VAI) with insulin resistance in adults with prediabetes. This cross-sectional study was done among 117 adults with newly detected prediabetes [m/f; 23/94; mean ± SD: Age 36.30 ± 9.99 years, BMI 28.89 ± 4.35 kg/m2] based on American Diabetes Association 2018 criteria and 141 matched healthy controls [m/f: 28/113; mean ± SD: 35.30 ± 6.88 years, BMI 25.03 ± 4.58]. Waist circumference, body mass index, fasting triglyceride, HDL cholesterol, fasting blood glucose and insulin were measured in each group to calculate VAI and homeostatic model assessment of insulin resistance (HOMA-IR). People with prediabetes had significantly higher median value of VAI {3.08 (2.26) vs. 1.86 (2.31); p < 0.001} with higher frequency of high VAI (>1) (98.3% vs. 85.8%; p < 0.001) than the control population. HOMA-IR level was significantly higher in prediabetes with high VAI (cut-off of 2.64) than control with normal VAI [2.78 (2.22, 4.15) vs. 2.20 (1.53, 3.36); p = 0.002]. VAI was positively correlated with HOMA-IR in females with prediabetes (r = 0.299, p = 0.003). VAI had predictive association with prediabetes [OR (95% CI: 9.504 (2.173, 41.576); p = 0.03] and high insulin resistance (HOMA-IR ≥ 2.6) in females with prediabetes [OR (95% CI) = 3.50 (1.476, 8.297); p = 0.004] only. It could satisfactorily discriminate prediabetes in both sexes (male: AUC = 0.767, p = 0.001; female: AUC = 0.641, p < 0.001) and high insulin resistance in females with prediabetes (AUC = 0.641; p = 0.019) only. So, VAI was associated with prediabetes and insulin resistance only in females with prediabetes.
Share and Cite:
Shahed-Morshed, M. , Haq, T. , Fariduddin, M. , Parveen, S. , , T. , Mahbub, N. and Hasanat, M. (2021) The Association of Visceral Adiposity Index with Insulin Resistance in Adults with Prediabetes.
Open Journal of Endocrine and Metabolic Diseases,
11, 12-23. doi:
10.4236/ojemd.2021.111002.