Ontogenes and the Paradox of Homologous Pairing ()
ABSTRACT
The mutations in ontogenes have been shown to drastically
increase the nondisjunction of X chromosomes in the D. melanogaster meiosis. This means that ontogenes are involved in the
process that brings the homologs together although both the genes and ontogenes
are finally paired. The phenomenon named the paradox of homologous pairing is described.
Chromosomal rearrangements (inversions and translocations) lead to formation of
specific topological figures (loops and crosses) during pairing. The mutual arrangement
of the nucleotide sequences of homologous ontogenes before and after formation of
such figures is different. Their arrangement coincides after a figure is formed
and the pairing looks homologous. However, before the figure is formed, their arrangement
does not match and the pairing is actually nonhomologous. The available data on
ontogenes allows this paradox to be resolved. It is assumed that the sequence of
each ontogene possesses a factor that 1) is a product of this nucleotide sequence;
2) is co-located with this sequence; and 3) generates approaching independently
of nucleotide sequence position in space. The sole candidate to the role of this
factor is the DNA conformation of ontogene. The conformation in the form of a solenoid
of DNA is able to generate an electromagnetic field independent of the orientation of the DNA itself. The
proposed resolution of the paradox is considered in terms of the problem of genetic
homology.
Share and Cite:
Chadov, B.F. and Fedorova, N.B. (2021) Ontogenes and the Paradox of Homologous Pairing.
Advances in Bioscience and Biotechnology,
12, 1-9. doi:
10.4236/abb.2021.121001.