Author(s)

Ola Røkke^1,2*, Thomas Heggelund¹, Jūratė Šaltytė Benth^2,3, Marianne Steffensen Røkke⁴, Kjell Øvrebø⁵

¹Department of Digestive Surgery, Akershus University Hospital, Lorenskog, Norway.
²Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
³Health Services Research Unit, Akershus University Hospital, Lorenskog, Norway.
⁴Department of Head and Neck Surgery, Akershus University Hospital, Lorenskog, Norway.
⁵Department of Digestive Surgery, Haukeland University Hospital, Bergen, Norway.

Purpose: To identify clinical predictors for reduced long-term survival and describe the cause of death after surgical treatment for rectal cancer. Methods: A retrospective follow-up study of 442 consecutive, unselected patients treated for rectal cancer at a tertiary centre from 1990 until 2000 and followed for 17 years or until death. Predictors for death were assessed by Cox regression analysis. The cause of death was obtained from the Norwegian Cause of Death Registry. Results: 254 men and 188 women with a median age of 71 years (21 - 95 years) were resected for rectal cancer with low anterior resection (n = 266), abdominoperineal resection (n = 125), Hartmann’s procedure (n = 19) or diverting stoma only (n = 32). Median follow-up was 5 years (0 - 17 years). The relative five-year survival rates for stages I, II, III and IV was 83.9%, 65.2%, 41.1% and 9.3%, respectively. The proportion of deaths due to recurrence from colorectal cancer in stages I, II, III and IV was 23.5%, 55.8%, 72.3% and 98.0%, respectively. Heart, lung and cerebrovascular disease and other malignancies were the cause of death in the other patients. Higher age, abdominoperineal resection compared to low anterior resection, lack of lymph node dissection compared to total mesorectal excision (TME), postoperative reoperations, TNM stages II and III compared to stage I and residual tumours after surgery were all significant independent predictors of reduced survival in the adjusted Cox regression model. Conclusions: Age, tumour stage, type of surgery, lymph node dissection, residual tumour after surgery and reoperations are predictors for survival after surgery for rectal cancer. In the patients who died, the cause of death was due to a condition other than colorectal cancer recurrence in 32.3% of the patients. The five-year relative survival rate was related to tumour stage.

Rectal Cancer, Predictors, Survival, Recurrence, Reoperation, Complication, Cause of Death

Røkke, O. , Heggelund, T. , Benth, J. , Røkke, M. and Øvrebø, K. (2021) Clinical Predictors for Reduced Long-Term Survival and Cause of Death after Curative Resection for Rectal Cancer. Journal of Cancer Therapy, 12, 31-46. doi: 10.4236/jct.2021.121004.