Author(s)

Ha Thi Thu Van¹, Hoang Xuan Quang¹, Vo Thi Bich Thuy², Nguyen Thai Son^1*

¹Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
²Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam.

The study is to identify trends and levels of antibiotic resistance of some common Gram-negative strains over time. The samples were collected from Vietnam Military Hospital 103 between 2014 and 2019. A total of 405 Acinetobacter baumannii., 528 Pseudomonas aeruginosa, 741 Escherichia coli, and 352 Klebsiella pneumoniae strains were identified and antimicrobial susceptibility was by Vitek system and Etest method. The multi-drug resistance (MDR) was major proportion of four common bacteria. In particular, there is a tendency to shift from MDR to Extended drug resistance (XDR) or possibly Pan drug resistant (pPDR). A. baumannii had the highest level of antibiotic resistance, namely, carbapenem (61.5% - 82.5%) and cephalosporin (72.7% - 88.7%). P. aeruginosa resisted most of commonly antibiotics, ranging from 50% to 70%. E. coli had a high resistance with antibiotics like ampicillin (87.2% - 97.6%) and the 3rd generation cephalosporins (up to 79.6%). K. pneumoniae resisted carbapenem from 14.7% to 44.4%, and other antibiotics with the higher rate of 40%. The collected data will be a prerequisite for further studies on mechanisms and factors related to antibiotic resistant bacteria, in order to find out a rational and effective using strategy of antibiotics.

Gram-Negative Bacteria, Antibiotic Resistance, Multi-Drug Resistance

Van, H. , Quang, H. , Thuy, V. and Son, N. (2020) The Five Years Surveillance and Trends of Antibiotic Resistance in Some Common Gram Negative Bacteria at the Vietnam Military Hospital. Advances in Microbiology, 10, 730-741. doi: 10.4236/aim.2020.1012052.