In real life, we want to understand our own health status and prevent the risk of disease outbreaks. We need to monitor the physical signs in real time, store and analyze the data, and call the police in time if there is an emergency. According to this requirement, this article designed a multifunctional portable smart health tester based on STM32F407, with Cprtex-M4 32-bit high-performance STM32F407ZGT6 microcontroller as the control core, HP-6 heart rate and blood pressure detection module, LCD screen display module, GSM module, The voice broadcast module is composed of not only the function of checking the time and date, setting the alarm clock, but also the functions of heart rate and blood pressure detection, voice broadcast, SMS sending, etc., to provide safety guarantee for the user’s health monitoring, and to prevent diseases and dangers in time. The system can accurately detect heart rate and blood pressure in real time and display it on the LCD screen. It can send fixed text messages, play fixed voices, realize alarm timing and modify time functions, and meet the daily needs of users. The GSM short message notification module and voice broadcast module in the design can be manually turned off by the user and the heart rate and blood pressure detection module is controlled by buttons to achieve low power consumption and humanization. It is suitable for users of all ages, especially the elderly. The non-invasive health tester designed in this paper can monitor and diagnose for a long time, and provide help for general users’ treatment before entering the hospital and nursing after leaving the hospital, and the implementation of monitoring provides protection for the health of users.