Author(s)

Mohammad Al-Masum^*, Houra A. Alalwan

Department of Chemistry, Tennessee State University, Nashville, TN, USA.

A mild, cascade type methodology was developed for the synthesis of polyphenolic ethers by the palladium-catalyzed cross coupling of phenols and halo compounds under microwave heating. In most cases, reactions run in neat conditions and in some cases, IPA/water mixture, and 1,4-dioxane were employed as solvents to furnish the products. By applying this new method, we were able to synthesize and purify a good number of polyether compounds with complete spectral data.

Polyphenolic Ether, Cross-Coupling, Cascade Type Reaction, Microwave Heating

Al-Masum, M. and Alalwan, H. (2020) Microwave Irradiated Palladium-Catalyzed Cascade Type Cross Coupling of Phenols and Halides for the Synthesis of Polyphenolic Ethers. International Journal of Organic Chemistry, 10, 135-143. doi: 10.4236/ijoc.2020.104010.