Author(s)

Sania Hossain^1*, Suraya Sultana², Khan Md. Shahariar Zaman³, Sabrina Shafiq³, A. K. M. Shahidur Rahman⁴, Shah Md. Zakir Hossain⁴, Saiful Islam⁵, Mahammod Selim Uddin⁶, Md. Omar Faroque⁴, Sheuly Ferdoushi³, Debatosh Paul³, Md. Quddusur Rahman³

¹Department of Cytopathology, National Institute of Cancer Research and Hospital (NICRH), Dhaka, Bangladesh.
²Laboratory Services Division, Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh.
³Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
⁴Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
⁵Department of Hepatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
⁶Department of Medicine, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh.

Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. There is no specific biomarker for the diagnosis of NAFLD. Trigly-ceride and glucose index (TyG) may predict the subsequent occurrence of NAFLD in later life. This cross sectional study was aimed to evaluate the effectiveness of triglyceride and glucose index (TyG) as a possible biomarker of NAFLD. The study was conducted at the Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2019 to February 2020. A total of 124 subjects were taken as study population following selection criteria. Among them 62 were diagnosed patients of NAFLD and 62 were healthy subjects as control group. Fasting plasma glucose was measured by glucose oxidase method and serum triglyceride was measured by enzymatic-colorimetric method, while TyG index was calculated accordingly. The mean age was 39.5 ± 11.27 years in NAFLD patients and 37.10 ± 12.28 years in control subjects with male female ratio 1:1.7 and 1:1.8 respectively. Major portion of NAFLD patients (62.9%) were overweight (BMI ≥ 25). The mean fasting plasma glucose level was 5.73 ± 1.47 mmol/L in NAFLD patients and 5.27 ± 0.69 mmol/L in control group (p < 0.027). The mean serum triglyceride level was 237.19 ± 96.47 mg/dl in NAFLD patients and 117.32 ± 53.07 mg/dl in control group (p < 0.001). The triglyceride and glucose index (TyG) was 9.36 ± 0.47 in NAFLD group and 8.53 ± 0.42 in control group. TyG index was significantly higher in NAFLD patients in comparison to control group (p < 0.001). In ROC analysis, cut off value of TyG index was 8.85 with sensitivity 93.5% and specificity 79%. As a fast and effective method, TyG index can be used as a diagnostic tool to predict NAFLD.

Non-Alcoholic Fatty Liver Disease (NAFLD), Plasma Glucose, Serum Triglyceride, Triglyceride and Glucose Index (TyG)

Hossain, S. , Sultana, S. , Zaman, K. , Shafiq, S. , Rahman, A. , Hossain, S. , Islam, S. , Uddin, M. , Faroque, M. , Ferdoushi, S. , Paul, D. and Rahman, M. (2020) Triglyceride and Glucose Index (TyG) is a Reliable Biomarker to Predict Non-Alcoholic Fatty Liver Disease. Journal of Biosciences and Medicines, 8, 124-136. doi: 10.4236/jbm.2020.811012.