Author(s)

P. K. Uduagbamen^1,2*, A. T. Oyelese³, A. O. Adebola Yusuf⁴, O. F. Salami⁵, C. M. Nwinee¹, M. I. Ogunmola¹, O. Ehioghae¹

¹Division of Nephrology and Hypertension, Department of Internal Medicine, Ben Carson School of Medicine, Babcock University/Babcock University Teaching Hospital, Ilishan-Remo, Nigeria.
²Nephrology Unit, Department of Internal Medicine, Federal Medical Centre, Abeokuta, Nigeria.
³Department of Haematology and Blood Transfusion, Ben Carson School of Medicine Babcock University/Babcock University Teach-ing Hospital, Ilishan-Remo, Nigeria.
⁴Division of Radiology, Department of Surgery, Ben Carson School of Medicine Babcock University/Babcock University Teaching Hospital, Ilishan-Remo, Nigeria.
⁵Intensive Care Unit, Department of Surgery, Ben Carson (Snr) School of Medicine, Babcock University/Babcock University Teaching Hospital, Ilishan-Remo, Nigeria.

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) use is very common. NSAIDs use could be associated with elevated eosinophil count which could be a class effect or patient-related. Inflammation could be the link between NSAIDs use and eosinophilia. Aims: To compare the pattern of eosinophil count in the peripheral blood of frequent users of NSAIDs and healthy controls. Methodology: Two hundred (one hundred frequent users of NSAIDs and 100 healthy controls) participants who had no known risk factor for kidney disease and had given informed consent were recruited. Blood was taken to determine the white cell count and differentials, serum electrolyte and creatinine, and random blood sugar. Results: The mean age of NSAIDs users was not significantly different from controls, P = 0.3. The mean eosinophil count was higher in males than females. The incidence of eosinophilia in NSAIDs users was 4%. The mean Eosinophil count of NSAIDs users was insignificantly higher than controls, 164.3 ± 51 6 vs 135. 6 ± 53.4, P = 0.4. The mean platelet count of NSAIDs users was significantly higher compared to controls, P = 0.04. The mean hematocrit of NSAIDs users was significantly lower than the controls, P = 0.02. Propionic acid derivatives were associated with the highest eosinophil count. Eosinophil count was positively related to age and serum creatinine and inversely related to blood glucose, hematocrit and glomerular filtration rate. Conclusion: The incidence of eosinophilia was 4%. The eosinophil count was higher in frequent NSAIDs users than occasional and non-users, in males than females and with use propionic acid derivatives compared to other NSAIDs. The Eosinophil count was positively related to age and platelet count. Being commoner in inflammatory states, the tissue destruction associated with elevated EC can be avoided by the prevention and prompt treatment of inflammatory conditions.

Eosinophilia, Kidney Function, Non-Steroidal Anti-Inflammatory Drugs, Hematocrit, Platelet Count, Propionic Acid

Uduagbamen, P. , Oyelese, A. , Adebola Yusuf, A. , Salami, O. , Nwinee, C. , Ogunmola, M. and Ehioghae, O. (2020) The Pattern of Eosinophil Count among Nigerians with Frequent Use of the Commonly Available Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). International Journal of Clinical Medicine, 11, 605-617. doi: 10.4236/ijcm.2020.1110051.