Author(s)

Saharé Fongoro^1,2, Magara Samaké^2,3, Seydou Sy^1,2*, Hamadoun Yattara^1,2, Djénèba Diallo^1,2, Jacques Coulibaly⁴, Moctar Coulibaly⁵, Aboubacar Sidiki Fofana¹, Atabième Kodio¹, Djénéba Maiga⁶, Aboudou M. Dolo⁶, Moustapha Tangara^1,2, Nouhoum Coulibaly¹, Brahima Dégoga¹, Ibrahima Koné⁷

¹Nephrology and Haemodialysis Department of the University Teaching Hospital of Point-G, Bamako, Mali.
²Faculty of Medicine of Bamako, Bamako, Mali.
³Nephrology Unit of the Fousseyni DAOU Hospital in Kayes, Kayes, Mali.
⁴Nephrology Unit of Ségou Hospital, Ségou, Mali.
⁵Nephrology Unit of the Mali GAVARDO Hospital of Sébénicoro, Bamako, Mali.
⁶Nephrology Unit of Sikasso Hospital, Sikasso, Mali.
⁷Nephrology Unit of Somino DOLO Hospital in Mopti, Mopti, Mali.

Beta-2-microglobulin (B2M) is a low molecular weight polypeptide (11,800 Da) that exists in a free form and a form bound to cell membranes (light chains of HLA class I molecules). Their dosage is used in the exploration and monitoring of renal function in haemodialysis patients, hence the interest of this study, the objective of which is to study the different players involved in the increase of beta-2-microglobulin. Materials and Methods: This was a prospective and descriptive study from January 1^st, 2017 to August 31, 2017 (08 months). All patients with chronic hemodialysis for 3 years or more were included. We analyzed sociodemographic, clinical and paraclinical data. Results: We collected 50 patients. The mean age was 50 ± 4.6 years with extremes of 30 and 82 years. The female sex predominated (52%). Chronic end-stage renal failure was hypertensive (86%), diabetic (4%). All patients benefited from intermittent hemodialysis for 8 hours per week using a low permeability membrane (cuprophane). The average duration of hemodialysis was 68 ± 6.4 months with extremes of 36 and 204 months. Twenty percent (20%) and four percent (4%) of chronic dialysis patients had joint pain and sensory deficit. Phalen’s sign was positive in 2% (1 case), Tinel’s sign in 2% (1 case) and carpal tunnel syndrome in 2% (1 case). The mean serum beta-2-microglobulin level was 58.34 ng/l with extremes of 16.99 and 112.24 ng/l. There was a correlation between hypertensive nephropathies and beta-2-microglobulin levels above 50 ng/l (P < 0.001). The mortality rate was 6%. Conclusion: Our study has objectified factors such as inadequate dialysis (8 hours/week), use of low permeability membrane in the increase of beta-2-microglobulin. The increase in serum beta-2-microglobulin levels in our patients is evidence of poor purification of medium molecules. Its reduction can be established by improving the quality of dialysis, in particular by using a high-permeability membrane.

Chronic Hemodialysis, Beta-2-Microglobulin, Carpal Tunnel Syndrome

Fongoro, S. , Samaké, M. , Sy, S. , Yattara, H. , Diallo, D. , Coulibaly, J. , Coulibaly, M. , Fofana, A. , Kodio, A. , Maiga, D. , Dolo, A. , Tangara, M. , Coulibaly, N. , Dégoga, B. and Koné, I. (2020) Interest of Beta-2-Microglobilin Plasma Assay in Iterative Haemodialysis in the Nephrology and Haemodialysis Department of University Teaching Hospital of Point G, Bamako, Mali. Open Journal of Nephrology, 10, 282-289. doi: 10.4236/ojneph.2020.104028.