Author(s)

Yafei Bao¹, Liang Zhen¹, Hui Wang², Hang Su³, Chang Chen³, Bo Jiang¹, Lei Zhang^1*

¹The Third Affiliated Hospital of Soochow University, Changzhou, China.
²Department of Pathology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
³Department of Thoracic Surgery, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China.

Objective: To analyze the relationship between micropapillary pattern (MIP) and tumor spread through air space (STAS) and postoperative survival rate in patients with lung adenocarcinoma ≤ 2 cm. Methods: Retrospective analyses were performed on clinical data of 575 patients with lung adenocarcinoma ≤ 2 cm, which were resected from 2009 to 2011. We analyzed the pathological findings on the resected specimens, with special reference to the presence/absence MIP and STAS, which have been reported to be a marker of poor prognosis of lung adenocarcinoma. Patients were divided into three according to the presence/absence of MIP and STAS: low-risk (MIP- STAS-), medium-risk (either MIP or STAS + (one plus)) and high-risk group (+/+: double plus). Endpoint was postoperative survival rate, which was compared among three groups. Results: There was no statistical difference in age, sex, and serum CEA level among three groups. In lobectomized patients, there was no statistical difference in prognosis among three groups; however, in sub-lobectomy group, patients with double + (+/+ for MIP and STAS) showed a lower survival rate than others (P < 0.001). Conclusion: The presence of MIP and STAS reduced the survival rate in sub-lobectomized patients.

Micropapillary, Spread through Air Space, Lobectomy, Sub-Lobectomy, Prognosis

Bao, Y. , Zhen, L. , Wang, H. , Su, H. , Chen, C. , Jiang, B. and Zhang, L. (2020) Effect of Micropapillary Pattern and Spread through Air Space in Patients with Lung Adenocarcinoma ≤ 2 cm. Journal of Cancer Therapy, 11, 597-604. doi: 10.4236/jct.2020.1110050.