Introduction: the objective of this work was to contribute to the improvement of the management of tuberculosis and to the reduction of the rate of abandonment of the anti-tuberculosis treatment by the determination of the associated factors in the city of Mbuji-Mayi. Method: the study is quantitative, it is kind of descriptive correlational. The sample is non-probabilistic of the accidental type, the size of which is 36 subjects. Results: 1) About the rate of discontinuation of anti-tuberculosis treatment: Our results CON anoint that of the total of 3029 tuberculosis patients who visited the health structures of these two health zones, 36 had discontinued treatment, a rate of 1.18%. On 36 cases of abandonment, 9 cases (or 25%) had resumed treatment and 27 cases (75%) had completely abandoned. 2) A Factors associated with total discontinuation of treatment: The association between total abandonment of treatment and more variables of our study revealed that the middle of transport (χ2 21.9440, p 0.049), consideration of the dignity of the per ringing in taking load (χ2 25 4357, p 0.019) and the number of the tablets as a result of abandonment (χ2 5.4152, p 0.019) are associated with the total abandonment of TB treatment. Conclusion: Despite all the concerted efforts to reduce the burden of tuberculosis, the latter remains globally significant. Strengthening health systems for early detection of tuberculosis and improving the quality of tuberculosis care, including rapid and accurate diagnosis, early initiation of treatment and regular monitoring, are priorities. Countries with higher TB rates than expected for their level of socio-demographic development should study not only the reasons for late consultation of TB patients, but also those related to the problem of discontinuing treatment and take corrective action.