Immobility Responses Affected by Potassium in Old Rats - Pharmacology & Pharmacy

PP > Vol.11 No.9, September 2020

Pharmacology & Pharmacy

Volume 11, Issue 9 (September 2020)

ISSN Print: 2157-9423 ISSN Online: 2157-9431

Google-based Impact Factor: 0.70 Citations h5-index & Ranking

Immobility Responses Affected by Potassium in Old Rats ()

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DOI: 10.4236/pp.2020.119021 365 Downloads 944 Views Citations

Author(s)

Linda Garcés-Ramírez¹, Oscar O. Morales-Dionisio¹, Gonzalo Flores², José Luna-Muñoz^3,4, Fidel de la Cruz^1*

Affiliation(s)

¹Departamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.
²Laboratorio de Neuropsiquiatría, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, México.
³National Dementia BioBank, Ciencias Biológicas, Facultad de Estudios Superiores, Cuautitlán, UNAM, Estado de México, México.
⁴Departamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.
⁴Banco Nacional de Cerebros-UNPHU, Universidad Nacional Pedro Hernríquez Ure?a, Santo Domingo, República Dominicana.

ABSTRACT

Four immobility responses (IR): elicited by clamping, bandaging, grasping and inversion, and their modification by potassium and spironolactone was studied in old Wistar rats (body weight, 500 g). When undrugged, only clamping and grasping, but not bandaging and inversion induced an IR in rats. Potassium and spironolactone significantly enhanced the duration of IR induced by clamping but not by grasping. They also induced an immobility response by bandaging, but not by inversion. The data suggest that IR induced by clamping and bandaging are somehow related to changes in the potassium serum levels. Consequently, such a relationship may be a suitable model to study some forms of paralysis in human beings which are related to changes in the potassium serum levels.

KEYWORDS

Immobility Responses (IR), Potassium, Spironolactone, Hyperkalemia, Familial Periodic Paralysis

Share and Cite:

Garcés-Ramírez, L. , Morales-Dionisio, O. , Flores, G. , Luna-Muñoz, J. and Cruz, F. (2020) Immobility Responses Affected by Potassium in Old Rats. Pharmacology & Pharmacy, 11, 235-250. doi: 10.4236/pp.2020.119021.

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