Author(s)

Jing Liu^1,2, Yanwen Xu², Tingting Wu¹, Xia Liu^1*, Yanhua Sun^1*

¹Department of Pathology, Shenzhen University 1st Affiliated Hospital, Shenzhen Second People’s Hospital, School of Medicine, Shenzhen University, Shenzhen, China.
²Department of Neurosurgery and Shenzhen Key Laboratory of Neurosurgery, Shenzhen University 1st Affiliated Hospital, Shenzhen Second People’s Hospital, School of Medicine, Shenzhen University, Shenzhen, China.

Objective: Abnormal miRNA expression is observed in several human tumors; moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. We aimed to investigate the role of miR-637 in gliomas. Methods: We assessed miR-637 expression in 98 and 16 gliomas and non-tumoral brain tissues, respectively, using in situ hybridization. We calculated receiver operating characteristic curves to determine the specificity and sensitivity of miR-637 biomarkers. Next, the effects of miR-637 on glioma cell migration and invasion were determined by using the transwell assay. Candidate target genes were identified through Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Results: There was significant miR-637 downregulation in glioma tissues (P < 0.001). Further, it showed potential as a diagnostic biomarker for gliomas. In addition, miR-637 suppressed glioma cell migration and invasion. Conclusions: Our findings suggest that miR-637 inhibits glioma invasion and migration and could be a potential diagnostic marker for gliomas. Future studies should examine the potential mechanisms underlying miR-637 as a diagnostic marker and therapeutic target for gliomas.

miR-637, Glioma, Diagnosis, Biomarkers

Liu, J. , Xu, Y. , Wu, T. , Liu, X. and Sun, Y. (2020) Tumor Suppressor miR-637 Is Associated with Cellular Migration, Invasion, and Glioma Diagnosis. International Journal of Clinical Medicine, 11, 516-525. doi: 10.4236/ijcm.2020.119044.