Author(s)

M. Abdelbary¹, A. Al-Sayyad¹, M. Menesy², M. Nasreldin³, R. Mostafa⁴, A. Nawito⁵, R. Marzaban^1*

¹Tropical Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
²Gastrointestinal Endoscopy Unit, Cairo, Egypt.
³Psychiatry Department, Faculty of Medicine, Cairo University, Giza, Egypt.
⁴Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
⁵Clinical Neurophysiology Department, Faculty of Medicine, Cairo University, Giza, Egypt.

Background and Aim: Irritable bowel syndrome (IBS) is a common medical disorder that may be severe enough to impair the quality of life. This study aimed to assess the role of each of dietary, psychiatric, autonomic, and microbiology background and their interactions in Egyptian patients with IBS. Patients and Methods: Forty adult patients diagnosed with IBS, equally divided into 2 groups the diarrhea predominant and the constipation predominant, were recruited from the Endoscopy Unit. Dietary assessment was done by monthly food frequency questionnaire. Psychiatric assessment was done by both the Eysenck Personality Questionnaire (EPQ) and Hopkins Symptom Checklist (HSCL-90). Microbiologic evaluation was done by faecal cultures and neurophysiologic autonomic evaluation was done via the sympathetic skin response and the parasympathetic R-R interval variation. Another 20 healthy subjects were included as control group. Results: All IBS patients were young, with significant female predominance (P = 0.007), particularly in IBS-C group (20/20; 100%, P = 0.003). Psychologically, abnormal scores of neuroticism, extraversion and criminality, and depression, obsessive compulsion, somatization, sensitivity and anxiety in both IBS groups with particularly extraversion, criminality and depression were significantly higher in constipation subtype. Microbiologically, Bacteroids were significantly related to IBS, while Klebsiella was significantly deficient without significant difference between its groups. On the contrary, neither diet nor autonomic activity showed any significant relation. Conclusions: IBS is a disorder induced by many factors and affected by several interacting agents, thus revealing controversial results when studied simultaneously.

Irritable Bowel Syndrome (IBS), Eysenck Personality Questionnaire (EPQ), Hopkins Symptom Checklist (HSCL-90), Microbiota, Autonomic Activity

Abdelbary, M. , Al-Sayyad, A. , Menesy, M. , Nasreldin, M. , Mostafa, R. , Nawito, A. and Marzaban, R. (2020) A Simultaneous Multidisciplinary Evaluation of Irritable Bowel Syndrome in Egyptian Patients: Dietary, Psychiatric, Microbiologic and Autonomic Aspects. Open Journal of Gastroenterology, 10, 214-230. doi: 10.4236/ojgas.2020.108021.