Author(s)

S. Laurentino¹, E. B. Sougey^2,3

¹Clinic of Behavioral Neurology and Neurophysiology, Recife, Brazil.
²Post Graduate Program of Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco, Recife, Brazil.
³Department of Neuropsychiatry, Federal University of Pernambuco, Recife, Brazil.

In the last years, some studies have shown that behavior disorder seems in frontotemporal dementia is related to dysfunction in the fronto-subcortical circuitry. Objectives: We did a narrative literature review concerning fronto-subcortical circuitry and frontotemporal dementia (FTD). Methods: Manuscripts related to fronto-subcortical network and frontotemporal dementia were selected for further analysis. Results: From the executions of simple motor actions to the most complex behaviors like goal-direct behavior and social cognition, the fronto-subcortical circuitry involves an intrigued network of fibers that reaches to basal ganglia nuclei. Recently, researchers have shown five parallel fronto-subcortical circuits integrating and segregating information from the frontal cortex to basal ganglia. Understanding the relationship between the fronto-subcortical circuit dysfunctions and neurodegenerative diseases requires studying the functional anatomy and neurochemical basis involved. Conclusions: In this view, it is essential to review the functional anatomy of the fronto-subcortical network, and it’s correlated with clinical aspects to pursuing a better therapeutic approach.

Frontotemporal Dementia, Fronto-Subcortical Circuitry, Basal Ganglia, Neurotransmitters, Fronto-Subcortical Syndrome

Laurentino, S. and Sougey, E. (2020) Dysfunction of Fronto-Subcortical Circuitry in Fronto-Temporal Dementia. Open Journal of Psychiatry, 10, 171-186. doi: 10.4236/ojpsych.2020.104015.