Study on the Correlation between the Expression of Serum Ferritin and Gestational Diabetes Mellitus ()
ABSTRACT
Objective: To explore the relationship between serum ferritin (SF) and gestational diabetes mellitus (GDM), for providing new ideas to
the prevention and treatment of GDM. Methods: All the pregnant women were selected in Yinan Maternal and Child
Health-Care Hospital from December, 2015 to
March, 2018 when they were having routine prenatal examination, According to
the diagnostic criteria of GDM, 72 patients with GDM were selected as the case
group and 72 normal pregnant women were randomly
selected as the control group. Fasting venous blood was drawn from
all subjects during the first trimester of pregnancy (11-13 weeks) and the second
trimester of pregnancy (24-28 weeks). Fasting plasma glucose was
measured by glucose oxidase assay and the expression level of SF was determined
by electrochemical method. The application value of SF in GDM diagnosis was
evaluated by ROC curve. Results: The levels of SF in the case group at
early and middle stages are 49.6 ± 18.8 (μg/ml) and
39.8 ± 21.5 (μg/ml), which re 39.4 ± 15.2 (μg/ml) and 32.2 ± 17.6 (μg/ml) in the control group. The levels of SF in the case group were higher than those in the control group (p < 0.05) at early and middle stages. The curve (AUC) of SF
level in the diagnosis of GDM was 0.895, p < 0.001; the Youden index was 0.651
and the optimum threshold was 38.6 ng/ml, with a sensitivity of 97.8% and a specificity of 67.3%. Conclusion: The expression level of SF in early pregnancy is correlated with the
occurrence of GDM, which may be an important indicator for the prevention and
monitoring of GDM.
Share and Cite:
Li, W. and Sun, Z. (2020) Study on the Correlation between the Expression of Serum Ferritin and Gestational Diabetes Mellitus.
Open Journal of Obstetrics and Gynecology,
10, 1135-1140. doi:
10.4236/ojog.2020.1080106.