Author(s)

Eman F. Kirolos¹, Amal S. Yanni^2*

¹College of Pharmacy, University of Florida, USA.
²Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt.

One pot criss-cross cycloaddition reaction of substituted 2,3-diaz-1,3-butadienes (1) and/or (2) with two equivalents of 2,3-dichloro-1,4-naphthoquinone in presence of dry benzene afforded bisnaphth[2,3-c]pyrazolidinetetrone derivatives (3) & (4). The chemical structure was achieved by elemental and spectral analysis. Biological activity of the synthesized compounds was tested against some micro-organisms, and has shown an interesting fungicidal activity and strongly to remarkable bactericidal activity.

Bispyrazolidine, Cycloaddition, Antimicrobial Activity

Kirolos, E. and Yanni, A. (2020) Synthesis of Some New Bispyrazolidine Derivatives for Biological Interest. International Journal of Organic Chemistry, 10, 104-110. doi: 10.4236/ijoc.2020.102007.