Author(s)

Mina Maher Raouf^1*, Hany Kamal Mikhail¹, Mohammad Ameen², Mohammed Awad Alsaeid³, Samar Magdy¹

¹Department of Anesthesia and ICU, Faculty of Medicine, El Minia University, El Minia, Egypt.
²Departement of Radiodiagnosis, Faculty of Medicine, El Minia University, El Minia, Egypt.
³Department of Anesthesia and Pain, Faculty of Medicine, El Fayoum University, El Fayoum, Egypt.

Severe preeclampsia is a challenging issue facing both intensivist and anesthetic team carrying both maternal and fetal morbidity and mortality. Termination of pregnancy after blood pressure control is the golden key in management. Cerebral complications due to diffuse cerebral vasospasm are most common and serious. Intrathecal midazolam with its gamma amino butyric action may antidote glutamate mediated sympathetic surge and decreasing cerebral vasospasm. Temporal view transcranial Doppler imaging maternal middle cerebral artery is used to examine blood flow indices namely pulsatility index and resistive index. One hundred ladies with severe preeclampsia scheduled for urgent caesarian section were recruited in 2 groups, both received 10 mg bupivacaine 0.5%, Midazolam group received 1 mg midazolam and the other group received 0.2 ml sterile saline 0.9% NaCl. All vascular indices were significantly better in midazolam group, less ICU stay.

Severe Preeclampsia, Transcranial Doppler, Midazolam, Spinal Anesthesia

Raouf, M. , Mikhail, H. , Ameen, M. , Alsaeid, M. and Magdy, S. (2020) Impact of Adding Midazolam to Bupivacaine 0.5% in Regional Spinal Anesthesia on Maternal Middle Cerebral Artery Velocimetry in Parturients with Severe Preeclampsia. Open Journal of Anesthesiology, 10, 232-246. doi: 10.4236/ojanes.2020.106021.