Author(s)

Mahmudul Hossain^1*, A. K. M. Shahidur Rahman², Samira Mahjabeen³, Mohona Zaman⁴, Mohaiminul Abedin⁵, Tahseen Mahmood⁶, Md. Abdur Razzaque⁷, Ummul Khair Alam⁸

¹Department of Medicine, Kurmitola General Hospital, Dhaka, Bangladesh.
²Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
³Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
⁴Department of Endocrinology, Monno Medical College Hospital, Manikganj, Bangladesh.
⁵Department of Anatomy, Abdul Malek Ukil Medical College, Noakhali, Bangladesh.
⁶Department of Endocrinology, BRB Hospital Limited, Dhaka, Bangladesh.
⁷Department of Dermatology, Khwaja Yunus Ali Medical College and Hospital (KYAMCH), Sirajganj, Bangladesh.
⁸Department of Maternal and Child Health (MCH), National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh.

Background: Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area. Objectives: To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). Methods: This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. Results: Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m²) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m²). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT; total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187; HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928; LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m². No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). Conclusions: Lipid profile does not differ between women with GDM and pregnant woman with NGT.

Gestational Diabetes Mellitus (GDM), Normal Glucose Tolerance (NGT), Serum Lipid Profile

Hossain, M. , Rahman, A. , Mahjabeen, S. , Zaman, M. , Abedin, M. , Mahmood, T. , Razzaque, M. and Alam, U. (2020) Comparison of Serum Lipid Profile between Gestational Diabetes Mellitus and Pregnant Women with Normal Glucose Tolerance. Journal of Biosciences and Medicines, 8, 148-159. doi: 10.4236/jbm.2020.86014.