Author(s)

Jiaying Zhou^1,2*, Quan Liu^2,3, Xianyue Ren², Bin Cheng^1,2, Tong Wu^1,2#

¹Department of Oral Medicine, Affiliated Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
²Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
³Zhujiang New Town Dental Clinic, Affiliated Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.

Oral potential malignant disorders (OPMDs), a series of local diseases with carcinogenic potential occurred in oral mucosa, have the possibility of developing into oral cancer. Effective diagnosis and surveillance at the early stage of OPMDs may be of help for interrupting the malignant transformation. In this review, we introduced the available non-invasive approaches of detecting the suspicious lesions, including vital staining, oral cytology, optical detection, saliva biomarkers detection, and image analysis, which can enhance the detection efficiency for the early diagnosis and surveillance of OPMDs. However, limitations which restrict the clinical application of these approaches still exist. How to improve the sensitivity and specificity of these techniques deserves further detailed study.

Oral Potential Malignant Disorders, Non-Invasive Detection Approaches, Malignant Transformation, Early Diagnosis, Surveillance

Zhou, J. , Liu, Q. , Ren, X. , Cheng, B. and Wu, T. (2020) Non-Invasive Approaches for Oral Potential Malignant Disorders Surveillance: A Review. Advances in Bioscience and Biotechnology, 11, 188-205. doi: 10.4236/abb.2020.115015.