International Journal of Clinical Medicine

Volume 11, Issue 5 (May 2020)

ISSN Print: 2158-284X   ISSN Online: 2158-2882

Google-based Impact Factor: 0.52  Citations  h5-index & Ranking

COVID-19 Coronavirus: Is Infection along with Mycoplasma or Other Bacteria Linked to Progression to a Lethal Outcome?

HTML  XML Download Download as PDF (Size: 424KB)  PP. 282-302  
DOI: 10.4236/ijcm.2020.115029    1,592 Downloads   13,602 Views  Citations

ABSTRACT

Most patients with COVID-19 disease caused by the SARS-CoV-2 virus recover from this infection, but a significant fraction progress to a fatal outcome. As with some other RNA viruses, co-infection or activation of latent bacterial infections along with pre-existing health conditions in COVID-19 disease may be important in determining a fatal disease course. Mycoplasma spp. (M. pneumonaie, M. fermentans, etc.) have been routinely found as co-infections in a wide number of clinical conditions, and in some cases this has progressed to a fatal disease. Although preliminary, Mycoplasma pneumoniae has been identified in COVID-19 disease, and the severity of some signs and symptoms in progressive COVID-19 patients could be due, in part, to Mycoplasma or other bacterial infections. Moreover, the presence of pathogenic Mycoplasma species or other pathogenic bacteria in COVID-19 disease may confer a perfect storm of cytokine and hemodynamic dysfunction, autoimmune activation, mitochondrial dysfunction and other complications that together cannot be easily corrected in patients with pre-existing health conditions. The positive responses of only some COVID-19 patients to antibiotic and anti-malaria therapy could have been the result of suppression of Mycoplasma species and other bacterial co-infections in subsets of patients. Thus it may be useful to use molecular tests to determine the presence of pathogenic Mycoplasma species and other pathogenic bacteria that are commonly found in atypical pneumonia in all hospitalized COVID-19 patients, and when positive results are obtained, these patients should treated accordingly in order to improve clinical responses and patient outcomes.

Share and Cite:

Nicolson, G. and de Mattos, G. (2020) COVID-19 Coronavirus: Is Infection along with Mycoplasma or Other Bacteria Linked to Progression to a Lethal Outcome?. International Journal of Clinical Medicine, 11, 282-302. doi: 10.4236/ijcm.2020.115029.

Cited by

[1] Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and–neonatal interactions of SARS-CoV-2, Zika, and …
… et Biophysica Acta (BBA …, 2022
[2] Long COVID and the Neuroendocrinology of Microbial Translocation Outside the GI Tract: Some Treatment Strategies
Endocrines, 2022
[3] Why are children and many adults not affected by COVID-19? Role of the host immune response
Infectious Diseases Research, 2022
[4] Pourquoi les enfants ne sont pas (ou très peu) atteints par la COVID-19?
2022
[5] Infecções secundárias em pacientes com Covid-19: uma revisão de literatura
2022
[6] Mycoplasma pneumoniae and Legionella pneu mophila co-infection with SARS-CoV-2 infections in COVID-19 patients living in Abadan, Iran
African …, 2021
[7] SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
… et Biophysica Acta (BBA …, 2021
[8] Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain
2021
[9] The role of co-infections and secondary infections in patients with COVID-19
2021
[10] Can Early Home administration of Azithromycin with Zinc Help Prevent Severe COVID-19 Disease Progression and Long-COVID?
2021
[11] COVID-19: Can early home treatment with Azithromycin alone or with Zinc help prevent hospitalisation, death, and long-COVID-19? A review
2021
[12] Temporal Positive-unlabeled Learning for Biomedical Hypothesis Generation via Risk Estimation
2020
[13] Humoral response to SARS-CoV-2 by healthy and sick dogs during COVID-19 pandemic in Spain
2020
[14] BBA-Molecular Basis of Disease
[15] Pourquoi les enfants et beaucoup d'adultes ne sont pas atteints par la COVID-19? Rôle de la réponse immunitaire de l'hôte

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.