Author(s)

Sama A. Al-Aghbari^1*, Omar M. Al-Shuja’a², Rowaida Al-Badani¹, Abd Al-Wali M. Japir^3,4

¹Chemistry Department, Faculty of Pharmacy, University of Science & Technology, Sana’a, Yemen.
²Chemistry Department, Faculty of Applied Science, Thamar University, Thamar, Yemen.
³CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China.
⁴Department of Chemistry, Faculty of Education, Thamar University, Dhamar, Yemen.

A New Schiff base ligand and its Pt (II) complex were synthesized. The ligand was prepared by condensation of 2-(4-isobutylphenyl)propanehydrazide with 2,3,4-trihydroxy benzaldehyde this novel ligand and its functional group was carefully designed and selected from well-known biological drugs. The structure of the ligand and its Pt-complex have been confirmed by spectroscopic data, i.e. elemental (CHN) analysis, FT-IR, electronic spectra, NMR spectra. The ligand and its Pt-complex were investigated for their in vitro anticancer potential using HeLa and PC3 cells. The Pt-complex showed a higher cytotoxic activity than the ligand towards Hela cells and PC3 cells.

Schiff Base, Complexes, Platinum, Anticancer Activity

Al-Aghbari, S. , Al-Shuja’a, O. , Al-Badani, R. and Japir, A. (2019) Synthesis, Characterization and Anticancer Activity Studies of New Schiff Base Pt (II) Complex. Journal of Materials Science and Chemical Engineering, 7, 1-8. doi: 10.4236/msce.2019.78001.