Author(s)

Reda M. Abdel Rahman¹, Abdulrahman S. Alharbi¹, Nawaa A. Alshammari^1,2*

¹Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Saudi Arabia.
²Department of Chemistry, Faculty of Science, Northern Borders University, Rafha, Saudi Arabia.

Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure of the products has been deduced upon their elemental analysis and spectral measurements. Most of the targets evaluated as enzymatic effect towards some bacteria (E. coli) in compare with Xanthine oxidase (from buttermilk) where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli.

Synthesis, 4-Thiazolidinones, Antipyrine, Inhibition of Purine Metabolism Enzymes, Bacteria

Rahman, R. , Alharbi, A. and Alshammari, N. (2019) Synthesis of Novel 4-Thiazolidinone and Bis-Thiazalidin-4-One Derivatives Derived from 4-Amino-Antipyrine and Evaluated as Inhibition of Purine Metabolism Enzymes by Bacteria. International Journal of Organic Chemistry, 9, 85-95. doi: 10.4236/ijoc.2019.92008.